Glucagon like Peptide-2 for Intestinal Stem Cell and Paneth Cell Repair during Graft-Versus-Host Disease in Mice and Humans

Investigators found that L-cells were a target of acute graft-versus-host disease (GVHD) and that glucagon-like-peptide-2-based treatment of acute GVHD restored intestinal homeostasis via an increase of intestinal stem cells and paneth cells without impairing graft-versus-leukemia effects.