A Chemokine Regulatory Loop Induces Cholesterol Synthesis in Lung-Colonizing Triple-Negative Breast Cancer Cells to Fuel Metastatic Growth

The primary TNBC tumor-derived C-X-C motif chemokines 1/2/8 stimulated lung resident fibroblasts to produce C-C motif chemokines 2/7, which in turn activated cholesterol synthesis in lung-colonizing TNBC cells and induced angiogenesis at lung metastatic sites.