MYC Hyperactivates WNT Signaling in APC/CTNNB1-Mutated Colorectal Cancer Cells through miR-92a-Dependent Repression of DKK3

Researchers examined the role of DKK3 by overexpression and knockdown and discovered that DKK3 suppressed Wnt signaling in APC-null murine colonic organoids and human colon cancer cells despite the presence of downstream activating mutations in the Wnt pathway.