A Potential Treatment of Congenital Sodium Diarrhea in Patients With Activating GUCY2C Mutations

Scientists investigated the effect of SSP2518 on guanylyl cyclase C (GCC)-mediated intracellular cyclic guanosine monophosphate levels and on GCC-mediated chloride secretion in intestinal organoids from three patients with distinct activating GCC mutations and from controls.