Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsTo better understand the effects of preeclampsia on angio-vasculogenesis and inflammatory networks in the fetus and to identify their biological signatures, researchers investigated the quantitative and functional characteristics of cord blood-derived mononuclear cells (MNCs) and CD31-positive MNCs.
[Scientific Reports]
6445212 {6445212:E85EZW3P} apa 50 1 159403 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-9ff399f1ad776453118c6786ee063da2%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22E85EZW3P%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cho%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECho%2C%20S.%2C%20Sohn%2C%20Y.-D.%2C%20Kim%2C%20S.%2C%20Rajakumar%2C%20A.%2C%20Badell%2C%20M.%20L.%2C%20Sidell%2C%20N.%2C%20%26amp%3B%20Yoon%2C%20Y.%20%282021%29.%20Reduced%20angiovasculogenic%20and%20increased%20inflammatory%20profiles%20of%20cord%20blood%20cells%20in%20severe%20but%20not%20mild%20preeclampsia.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%203630.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-83146-8%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-83146-8%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DE85EZW3P%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reduced%20angiovasculogenic%20and%20increased%20inflammatory%20profiles%20of%20cord%20blood%20cells%20in%20severe%20but%20not%20mild%20preeclampsia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seonggeon%22%2C%22lastName%22%3A%22Cho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Young-Doug%22%2C%22lastName%22%3A%22Sohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sangsung%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Augustine%22%2C%22lastName%22%3A%22Rajakumar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martina%20L.%22%2C%22lastName%22%3A%22Badell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neil%22%2C%22lastName%22%3A%22Sidell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Young-sup%22%2C%22lastName%22%3A%22Yoon%22%7D%5D%2C%22abstractNote%22%3A%22Preeclampsia%20%28PE%29%20is%20a%20prevalent%20pregnancy%20disorder%20that%20leads%20to%20high%20maternal%20and%20fetal%20morbidity%20and%20mortality.%20While%20defective%20vascular%20development%20and%20angiogenesis%20in%20placenta%20are%20known%20as%20crucial%20pathological%20findings%2C%20its%20pathophysiological%20mechanism%20remains%20elusive.%20To%20better%20understand%20the%20effects%20of%20PE%20on%20angio-vasculogenesis%20and%20inflammatory%20networks%20in%20the%20fetus%20and%20to%20identify%20their%20biological%20signatures%2C%20we%20investigated%20the%20quantitative%20and%20functional%20characteristics%20of%20cord%20blood-derived%20mononuclear%20cells%20%28CB-MNCs%29%20and%20CD31-positive%20MNCs.%20Flow%20cytometry%20analysis%20demonstrated%20that%20the%20CB-MNCs%20from%20the%20severe%20PE%20group%20had%20significantly%20decreased%20number%20of%20cells%20expressing%20CD3%2C%20CD11b%2C%20CD14%2C%20CD19%2C%20KDR%2C%20and%20CD31%20compared%20with%20the%20normal%20group.%20Quantitative%20real%20time%20PCR%20%28qRT-PCR%29%20shows%20down-regulation%20of%20the%20major%20angiogenic%20factor%20VEGFA%20in%20MNCs%20and%20CD31%2B%20MNCs%20in%20severe%20PE.%20The%20major%20inflammatory%20cytokines%20IL1%20was%20highly%20upregulated%20in%20CD31%2B%20CB-MNCs%20in%20the%20severe%20PE%20patients.%20Mild%20PE%20patients%2C%20however%2C%20did%20not%20display%20any%20significant%20difference%20in%20expression%20of%20all%20measured%20angiogenic%20genes%20and%20most%20inflammatory%20genes.%20These%20findings%20show%20distinct%20angiogenic%20and%20inflammatory%20signatures%20from%20severe%20PE%2C%20and%20they%20may%20play%20a%20significant%20role%20in%20the%20pathogenesis%20of%20vascular%20defects%20in%20placenta%20of%20severe%20PE.%22%2C%22date%22%3A%222021-02-11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-83146-8%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-83146-8%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-02-24T18%3A06%3A45Z%22%7D%7D%5D%7D
Cho, S., Sohn, Y.-D., Kim, S., Rajakumar, A., Badell, M. L., Sidell, N., & Yoon, Y. (2021). Reduced angiovasculogenic and increased inflammatory profiles of cord blood cells in severe but not mild preeclampsia. Scientific Reports, 11(1), 3630. https://doi.org/10.1038/s41598-021-83146-8 Cite
