Keep Current with the Latest in Cell Biology Research

Targeting the ERG Oncogene with Splice-Switching Oligonucleotides as a Novel Therapeutic Strategy in Prostate Cancer

In VCaP prostate cancer cells, both splice-switching oligonucleotides were effective at inducing exon 4 skipping, which resulted in a reduction of overall ERG protein levels up to 96 hours following a single transfection.
[British Journal of Cancer]
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E2F7, Regulated by miR‑30c, Inhibits Apoptosis and Promotes Cell Cycle of Prostate Cancer Cells

Transfection of miR‑30c mimicked into prostate cancer cells resulted in reduced cell viability, increased proportion of cells in the G1 phase and higher apoptotic rates.
[Oncology Reports]
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An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells

Combination with the BAD-like mimetic ABT-737 was examined on prostate cancer cells and 3D spheroids and in view of tumor growth and survival in the prostate cancer SCID mouse xenograft model.
[Cancers]
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The CHK1 Inhibitor MU380 Significantly Increases the Sensitivity of Human Docetaxel-Resistant Prostate Cancer Cells to Gemcitabine through the Induction of Mitotic Catastrophe

Both CHK1 inhibitors significantly potentiated the sensitivity to gemcitabine in a panel of chemo‐naïve and matched docetaxel‐resistant prostate cancer cell lines under 2D conditions.
[Molecular Oncology]
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AR Phosphorylation and CHK2 Kinase Activity Regulates IR Stabilized AR-CHK2 Interaction and Prostate Cancer Survival

The destabilization of androgen receptor-checkpoint kinase 2 (CHK2) interactions induced by CHK2 variants impaired CHK2 negative regulation of cell growth.
[eLife]
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Inhibition of Notch Pathway Enhances the Anti-Tumor Effect of Docetaxel in Prostate Cancer Stem-Like Cells

The effect of Notch inhibition on response to DOX was evaluated in prostate cancer stem-like cells in vitro and in murine models using a γ-secretase inhibitor, PF-03084014.
[Stem Cell Research & Therapy]
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Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis

The authors present an overview of the main cytokines/chemokines, including IL-6, CXCL12, TGFβ, CXCL8, VEGF, RANKL, CCL2, CX3CL1, IL-1, IL-7, CXCL1, and CXCL16, that exert modulatory roles in prostate cancer metastasis.
[International Journal of Molecular Sciences]
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Promotion of Epithelial Hyperplasia by interleukin-8-CXCR Axis in Human Prostate

The expression of the IL‐8 axis components was confined to the prostate luminal epithelial cells in both normal and benign prostatic hyperplasia tissues.
[Prostate]
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Comparison of Efficacy and Health-Related Quality of Life of First-Line Haploidentical Hematopoietic Stem Cell Transplantation with Unrelated Cord Blood Infusion and First-Line Immunosuppressive Therapy for Acquired Severe Aplastic Anemia

Scientists retrospectively compared the efficacy and health-related quality of life of first-line haploidentical hematopoietic stem cell transplantation combined with unrelated cord blood infusion and first-line immunosuppressive therapy in acquired severe aplastic anemia patients.
[Leukemia]
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Amending Microbiota by Targeting Intestinal Inflammation with TNF Blockade Attenuates Development of Colorectal Cancer

Using chemically induced and spontaneous mouse colorectal cancer (CRC) models colonized by colibactin-producing Escherichia coli, scientists established the role of microbiota in mediating the antitumorigenic effect of anti–tumor necrosis factor (TNF) therapy. They found that TNF blockade attenuated colitis and CRC development
[nature cancer]
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Natera Announces First Patient Enrollments in Both CIRCULATE-Japan and BESPOKE CRC Trials Using SignateraTM MRD Testing

Natera, Inc.announced that enrollment has begun in the CIRCULATE-Japan and BESPOKE CRC trials, with both studies experiencing strong interest from centers across Japan and the U.S The studies will measure clinical outcomes of Signatera molecular residual disease testing in resectable Stages II-IV colorectal cancer.
[Natera]
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