Keep Current with the Latest in Cell Biology Research

Pneumonia-Induced Endothelial Amyloids Reduce Dendritic Spine Density in Brain Neurons

Researchers used electrophysiological studies in brain slices and structural analysis of post-mortem tissues obtained from animals exposed to endothelium-derived amyloids. The amyloids were administered via three different routes, by intracerebroventricular, intratracheal, and intraperitoneal injections.
[Scientific Reports]
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miR-503-5p Inhibits Colon Cancer Tumorigenesis, Angiogenesis, and Lymphangiogenesis by Directly Downregulating VEGF-A

Scientists observed considerable downregulation of miR-503-5p expression in colon cancer cells and tissues and significant correlation with the TNM stage, differentiation grade and lymph node metastasis of colon cancer. Overexpression of miR-503-5p promoted the apoptosis and G1 arrest of colon cancer cells, and inhibited migration, proliferation, invasion and colony formation.
[Gene Therapy]
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Essential Contribution of Macrophage Tie2 Signaling in a Murine Model of Laser-Induced Choroidal Neovascularization

Scientists observed that Tie2-expressing macrophages prevented apoptosis of b.End3 cells, but promoted their migration, proliferation and tube formation via VEGF, extracellular signal-regulated kinase and v-akt murine thymoma viral oncogene-dependent signaling pathways.
[Scientific Reports]
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Neural Metabolic Imbalance Induced by MOF Dysfunction Triggers Pericyte Activation and Breakdown of Vasculature

The authors showed that neural-specific depletion of three members of the non-specific lethal chromatin complex—Mof, Kansl2 or Kansl3—unexpectedly led to severe vascular defects and brain hemorrhaging.
[Nature Cell Biology]
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Effects of Photobiomodulation on Annulus Fibrosus Cells Derived from Degenerative Disc Disease Patients Exposed to Microvascular Endothelial Cells Conditioned Medium

Researchers examined the effects of photobiomodulation (PBM), administered at various wavelengths and doses, on endothelial cell (EC)-stimulated human annulus fibrosus cells. Results showed that PBM selectively inhibited the EC-mediated production of inflammatory mediators, catabolic enzymes, and neurotrophins by human annulus fibrosus cells in a dose- and wavelength-dependent manner.
[Scientific Reports]
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Snail Promotes the Generation of Vascular Endothelium by Breast Cancer Cells

Investigators reported a new and unexpected function of Snail in endothelium generation by breast cancer cells. They showed that high Snail-expressing breast cancer cells isolated from patients showed more endothelium generated from these cells.
[Cell Death & Disease]
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Prediction of Post-Treatment Retinal Sensitivity by Baseline Retinal Perfusion Density Measurements in Eyes with Branch Retinal Vein Occlusion

Retinal sensitivity was measured using microperimetry and perfusion density was measured by optical coherence tomography angiography. Researchers also investigated the possibility that the PD, one month after anti-VEGF treatment, was a predictor of retinal sensitivity after one year of successful macular oedema management with anti-VEGF.
[Scientific Reports]
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Nanotechnology for Angiogenesis: Opportunities and Challenges

The authors summarize nanotechnology-based strategies that have been explored in the broad area of angiogenesis. Lipid-based, carbon-based and polymeric nanoparticles, and a wide range of inorganic and metallic nanoparticles are covered in detail.
[Chemical Society Reviews]
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Coupling of Melanocyte Signaling and Mechanics by Caveolae is Required for Human Skin Pigmentation

Investigators showed that caveolae were asymmetrically distributed in melanocytes and particularly abundant at the melanocyte-keratinocyte interface in epidermis.
[Nature Communications]
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Chronic Expression of p16INK4a in the Epidermis Induces Wnt-Mediated Hyperplasia and Promotes Tumor Initiation

Scientists found that prolonged expression of transgenic p16INK4a in the mouse epidermis induced hyperplasia and dysplasia, involving high proliferation rates of keratinocytes not expressing the transgene.
[Nature Communications]
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Massively Parallel Reporter Assays of Melanoma Risk Variants Identify MX2 as a Gene Promoting Melanoma

Researchers showed that melanocyte-specific expression of human MX2 in a zebrafish model demonstrated accelerated melanoma formation in a BRAFV600E background.
[Nature Communications]
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