Keep Current with the Latest in Cell Biology Research

Protection of Layers and Breeders against Homologous or Heterologous HPAIv by Vaccines from Korean National Antigen Bank

Researchers evaluated the efficacy of the clade 2.3.2.1c and 2.3.4.4c H5Nx vaccines from the Korean avian influenza national antigen bank for emergency preparedness for their potency and protective efficacy against lethal homologous and heterologous viruses in layer and breeder chickens practically.
[Scientific Reports]
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Downregulation of HLA-I by the Molluscum Contagiosum Virus Mc080 Impacts NK-Cell Recognition and Promotes CD8+ T-Cell Evasion

MC080, but not MC033, downregulated cell-surface expression of endogenous classical human leucocyte antigen (HLA) class I and non-classical HLA-E by a transporter associated with antigen processing-independent mechanism.
[Journal of General Virology]
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Influenza Virus-Induced Oxidized DNA Activates Inflammasomes

Investigators showed that influenza virus stimulated oxidized DNA release from macrophages. Ion channel activity of the M2 protein or mitochondrial localization of the PB1-F2 protein was required for oxidized DNA release.
[iScience]
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From Threat to Cure: Understanding of Virus-Induced Cell Death Leads to Highly Immunogenic Oncolytic Influenza Viruses

The authors discuss strategies for targeting viral replication to cancerous lesions and arming them with immunogenic transgenes. They describe which modes of cell death are induced by influenza A virus infection and how these insights may be utilized to optimize influenza A virus-based oncolytic virus design.
[Cell Death Discovery]
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Adamis Pharmaceuticals Announces License to Commercialize Tempol, a Novel Investigational Anti-inflammatory and Antioxidant Drug for the Treatment of Respiratory Diseases Including COVID-19

Adamis Pharmaceuticals Corporation announced a license to commercialize Tempol, a novel patented investigational drug for the treatment of COVID-19. The license includes the worldwide use of Tempol for the treatment of all respiratory diseases including asthma, respiratory syncytial virus, influenza and COVID-19.
[Adamis Pharmaceuticals]
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Pluristem Announces Activation of Clinical Sites and Commencement of Patient Enrollment in US FDA Phase II COVID-19 ARDS Trial

Pluristem Therapeutics, Inc. announced the activation of clinical sites and initiation of enrollment in its Phase II US FDA study of PLX cells for the treatment of severe COVID-19 complicated by Acute Respiratory Distress Syndrome (ARDS).
[Pluristem Therapeutics, Inc. ]
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UCLA Receives Nearly $14 Million from NIH to Investigate Gene Therapy to Combat HIV

University of California, Lost Angeles (UCLA) researchers and colleagues have received a $13.65 million grant from the National Institutes of Health to investigate and further develop an immunotherapy known as CAR T, which uses genetically modified stem cells to target and destroy HIV.
[Univesity of California, Los Angeles]
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HIV-1-Associated Left Ventricular Cardiac Dysfunction in Humanized Mice

Longitudinal echocardiography was used to assess whether NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ mice reconstituted with human hematopoietic stem cells and infected with HIV-1ADA could recapitulate the salient features of HIV-1 infection.
[Scientific Reports]
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Considering How Biological Sex Impacts Immune Responses and COVID-19 Outcomes

The authors discuss available sex-disaggregated epidemiological data from the COVID-19 pandemic, introduce sex-differential features of immunity and highlight potential sex differences underlying COVID-19 severity.
[Nature Reviews Immunology]
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Neurons That Regulate Mouse Torpor

Scientists showed that entry into mouse torpor, a fasting-induced state with a greatly decreased metabolic rate and a body temperature as low as 20 °C, was regulated by neurons in the medial and lateral preoptic area of the hypothalamus.
[Nature]
Hrvatin, S., Sun, S., Wilcox, O. F., Yao, H., Lavin-Peter, A. J., Cicconet, M., Assad, E. G., Palmer, M. E., Aronson, S., Banks, A. S., Griffith, E. C., & Greenberg, M. E. (2020). Neurons that regulate mouse torpor. Nature, 1–7. https://doi.org/10.1038/s41586-020-2387-5 Cite
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A Discrete Neuronal Circuit Induces a Hibernation-Like State in Rodents

Investigators showed that a hypothalamic neuronal circuit in rodents induced a long-lasting hypothermic and hypometabolic state similar to hibernation.
[Nature]
Takahashi, T. M., Sunagawa, G. A., Soya, S., Abe, M., Sakurai, K., Ishikawa, K., Yanagisawa, M., Hama, H., Hasegawa, E., Miyawaki, A., Sakimura, K., Takahashi, M., & Sakurai, T. (2020). A discrete neuronal circuit induces a hibernation-like state in rodents. Nature, 1–6. https://doi.org/10.1038/s41586-020-2163-6 Cite
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