AKT

[Cell Reports] Scientists reported that low FBXO31 mRNA levels were associated with high pre-operative prostate-specific antigen levels and Gleason grade in human prostate cancer.

[Bioengineered] Scientists reported that the combination of curdione and docetaxel (DTX) strengthened the DTX-induced pro-apoptotic effects in TNBC cells and identified its involved signaling pathways.

[Metallomics] Researchers found that maternal selenium (Se) deficiency decreased placental Se concentration and expressions of some antioxidant selenoproteins.

[Haematologica] Researchers used single-cell mass cytometry to study signal transduction pathways such as the JAK-STAT, PI3K-AKT-mTOR and MEK-ERK pathways in 16 diagnostic and 5 relapsed T cell acute lymphoblastic leukemia primary samples and investigated the in vitro response of cells to interleukin-7 and the inhibitor BEZ-235.

[Scientific Reports] Researchers investigated the role of mTORC1 in regulating translationally controlled tumor protein levels, thereby modulating chemosensitivity, in human lung cancer cells and an A549 lung cancer xenograft model.

[Molecular Medicine] TRIM14 promoted the proliferation of acute myeloid leukemia cells via activating PI3K/AKT pathway, which was reversed by human MSC-derived exosomes through delivering miR-23b-5p.