ATR

[Cancer Research] Researchers report that TAK-243, a first-in-class ubiquitin activating enzyme UBA1 inhibitor in clinical development, caused preferential cytotoxicity in SLFN11-knock out cells.

[Cancer Cell] Using chemical genetic screens, scientists identified inhibition of ataxia telangiectasia and rad3 related (ATR), the primary activator of the replication stress response, and topoisomerase I (TOP1), nuclear enzyme that suppressed genomic instability, as synergistically cytotoxic in small cell lung cancer (SCLC).

[PLoS Biology] The authors report the implementation of CRISPR/Cas-9 genetic screening to identify susceptibilities of multiple A3A-expressing lung adenocarcinoma cell lines.

[EMBO Reports] The authors proposed that in addition to ataxia‐telangiectasia and Rad3 related (ATR), a MYBL2‐MRN‐ATM replication stress response pathway functioned in ESCs to control DNA replication initiation and prevent genome instability.

[Haematologica] Researchers demonstrated that loss of DEAD-box Helicase 41 (ddx41) led to anemia caused by diminished proliferation and defective differentiation of erythroid progenitors.

[Cell Reports] Scientists developed a medium-throughput drug screening system and identified a small molecule library of 34 of 430 protein kinase inhibitors that were capable of inhibiting SARS-CoV-2 cytopathic effect in human epithelial cells.