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Pulmonary Cell NewsResearchers report that TAK-243, a first-in-class ubiquitin activating enzyme UBA1 inhibitor in clinical development, caused preferential cytotoxicity in SLFN11-knock out cells.
[Cancer Research]
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Murai, Y., Jo, U., Murai, J., Jenkins, L., Huang, S.-Y. N., Chakka, S., Chen, L., Cheng, K., Fukuda, S., Takebe, N., & Pommier, Y. (2021). SLFN11 inactivation induces proteotoxic stress and sensitizes cancer cells to ubiquitin activating enzyme inhibitor TAK-243. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2694 Cite
