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B-lymphocytes

Pre-Mitotic Genome Re-Organisation Bookends the B Cell Differentiation Process

[Nature Communications] Scientists elucidated the chromosome conformational changes in B lymphocytes as they differentiated and expanded from a naive, quiescent state into antibody secreting plasma cells.

CD20 as a Gatekeeper of the Resting State of Human B Cells

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrated that CD20 controlled the nanoscale organization of receptors on the surface of resting B lymphocytes.

Signal-Transducing Adaptor Protein-2 Delays Recovery of B Lineage Lymphocytes during Hematopoietic Stress

[Haematologica] The authors exploited gene targeted and transgenic mice, and demonstrated that signal-transducing adaptor protein-2 was not required under normal, steady-state conditions.

The Influence of Tumor Microenvironment on Immune Escape of Melanoma

[International Journal of Molecular Sciences] The authors provides a comprehensive summary of the processes regulated by tumor-associated cells that promote the immune escape of melanoma cells.

Sustained Cellular Immune Dysregulation in Individuals Recovering from SARS-CoV-2 Infection

[Journal of Clinical Investigation] Researchers examined immune cell subsets in hospitalized and non-hospitalized individuals. In hospitalized patients, many adaptive and innate immune cells were decreased in frequency compared to healthy and convalescent individuals, with the exception of B lymphocytes which increased

Recurrent HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion

[Clinical Cancer Research] Researchers hypothesized that head and neck squamous cell carcinoma recurrent tumors successfully evade anti-tumor immune response and aimed to reveal tumor immune microenvironment changes of primary tumors.

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