Researchers hypothesized that head and neck squamous cell carcinoma recurrent tumors successfully evade anti-tumor immune response and aimed to reveal tumor immune microenvironment changes of primary tumors.
[Clinical Cancer Research]
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Watermann, C., Pasternack, H., Idel, C., Ribbat-Idel, J., Brägelmann, J., Kuppler, P., Offermann, A., Jonigk, D., Kühnel, M., Schröck, A., Dreyer, E., Rosero, C., Nathansen, J., Dubrovska, A., Tharun, L., Kirfel, J., Wollenberg, B., Perner, S., & Krupar, R. (2020). Recurrent HNSCC harbor an immunosuppressive tumor immune microenvironment suggesting successful tumor immune evasion. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-0197 Cite