Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsThe authors exploited gene targeted and transgenic mice, and demonstrated that signal-transducing adaptor protein-2 was not required under normal, steady-state conditions.
[Haematologica]
6445212 {6445212:RS3TZ9VY} apa 50 1 158587 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-58b96c171b24db9ab8b6b4e95693dbf7%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22RS3TZ9VY%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ichii%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EIchii%2C%20M.%2C%20Oritani%2C%20K.%2C%20Toda%2C%20J.%2C%20Saito%2C%20H.%2C%20Shi%2C%20H.%2C%20Shibayama%2C%20H.%2C%20Motooka%2C%20D.%2C%20Kitai%2C%20Y.%2C%20Muromoto%2C%20R.%2C%20Kashiwakura%2C%20J.%2C%20Saitoh%2C%20K.%2C%20Okuzaki%2C%20D.%2C%20Matsuda%2C%20T.%2C%20%26amp%3B%20Kanakura%2C%20Y.%20%282021%29.%20Signal-transducing%20adaptor%20protein-2%20delays%20recovery%20of%20B%20lineage%20lymphocytes%20during%20hematopoietic%20stress.%20%3Ci%3EHaematologica%3C%5C%2Fi%3E%2C%20%3Ci%3E106%3C%5C%2Fi%3E%282%29%2C%20424%26%23x2013%3B436.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3324%5C%2Fhaematol.2019.225573%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3324%5C%2Fhaematol.2019.225573%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DRS3TZ9VY%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Signal-transducing%20adaptor%20protein-2%20delays%20recovery%20of%20B%20lineage%20lymphocytes%20during%20hematopoietic%20stress%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michiko%22%2C%22lastName%22%3A%22Ichii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenji%22%2C%22lastName%22%3A%22Oritani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jun%22%2C%22lastName%22%3A%22Toda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hideaki%22%2C%22lastName%22%3A%22Saito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henyun%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hirohiko%22%2C%22lastName%22%3A%22Shibayama%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisuke%22%2C%22lastName%22%3A%22Motooka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuichi%22%2C%22lastName%22%3A%22Kitai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryuta%22%2C%22lastName%22%3A%22Muromoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jun-ichi%22%2C%22lastName%22%3A%22Kashiwakura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kodai%22%2C%22lastName%22%3A%22Saitoh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisuke%22%2C%22lastName%22%3A%22Okuzaki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tadashi%22%2C%22lastName%22%3A%22Matsuda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuzuru%22%2C%22lastName%22%3A%22Kanakura%22%7D%5D%2C%22abstractNote%22%3A%22Signal-transducing%20adaptor%20protein-2%20%28STAP-2%29%20was%20discovered%20as%20a%20C-FMS%5C%2FM-CSFR%20interacting%20protein%20and%20subsequently%20found%20to%20function%20as%20an%20adaptor%20of%20signaling%20or%20transcription%20factors.%20These%20include%20STAT5%2C%20MyD88%20and%20I%5Cu03baB%20kinase%20in%20macrophages%2C%20mast%20cells%2C%20and%20T%20cells.%20There%20is%20additional%20information%20about%20roles%20for%20STAP-2%20in%20several%20types%20of%20malignant%20diseases%20including%20chronic%20myeloid%20leukemia%2C%20however%2C%20none%20have%20been%20reported%20concerning%20B%20lineage%20lymphocytes.%20We%20have%20now%20exploited%20gene%20targeted%20and%20transgenic%20mice%20to%20address%20this%20lack%20of%20knowledge%2C%20and%20demonstrated%20that%20STAP-2%20is%20not%20required%20under%20normal%2C%20steady-state%20conditions.%20However%2C%20recovery%20of%20B%20cells%20following%20transplantation%20was%20augmented%20in%20the%20absence%20of%20STAP-2.%20This%20appeared%20to%20be%20restricted%20to%20cells%20of%20B%20cell%20lineage%20with%20myeloid%20rebound%20noted%20as%20unremarkable.%20Furthermore%2C%20all%20hematological%20parameters%20were%20observed%20to%20be%20normal%20once%20recovery%20from%20transplantation%20was%20complete.%20Furthermore%2C%20overexpression%20of%20STAP-2%2C%20specifically%20in%20lymphoid%20cells%2C%20resulted%20in%20reduced%20numbers%20of%20late-stage%20B%20cell%20progenitors%20within%20the%20bone%20marrow.%20While%20numbers%20of%20mature%20peripheral%20B%20and%20T%20cells%20were%20unaffected%2C%20recovery%20from%20sub-lethal%20irradiation%20or%20transplantation%20was%20dramatically%20reduced.%20Lipopolysaccharide%20%28LPS%29%20normally%20suppresses%20B%20precursor%20expansion%20in%20response%20to%20interleukin%207%2C%20however%2C%20STAP-2%20deficiency%20made%20these%20cells%20more%20resistant.%20Preliminary%20RNA-Seq%20analyses%20indicated%20multiple%20signaling%20pathways%20in%20B%20progenitors%20as%20STAP-2-dependent.%20These%20findings%20suggest%20that%20STAP-2%20modulates%20formation%20of%20B%20lymphocytes%20in%20demand%20conditions.%20Further%20study%20of%20this%20adapter%20protein%20could%20reveal%20ways%20to%20speed%20recovery%20of%20humoral%20immunity%20following%20chemotherapy%20or%20transplantation.%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3324%5C%2Fhaematol.2019.225573%22%2C%22ISSN%22%3A%221592-8721%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fhaematologica.org%5C%2Farticle%5C%2Fview%5C%2F9620%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-02-02T17%3A13%3A08Z%22%7D%7D%5D%7D
Ichii, M., Oritani, K., Toda, J., Saito, H., Shi, H., Shibayama, H., Motooka, D., Kitai, Y., Muromoto, R., Kashiwakura, J., Saitoh, K., Okuzaki, D., Matsuda, T., & Kanakura, Y. (2021). Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress. Haematologica, 106(2), 424–436. https://doi.org/10.3324/haematol.2019.225573 Cite
