CD8

[Immunity] The composition of the intestinal microbiota is associated with both the development of tumors and the efficacy of anti-tumor immunity. Researchers examined the impact of microbiota-specific T cells in anti-colorectal cancer immunity.

[G1 Therapeutics, Inc.] G1 Therapeutics, Inc. announced that the company has initiated a Phase II, single arm, open-label study of trilaciclib in patients with early-stage triple negative breast cancer designed to further investigate the role of trilaciclib in modulating the anti-tumor immune response.

[Cellular Immunology] Researchers examined tumor-infiltrating lymphocytes in colorectal cancer expressing different levels of SIRT1.

[Cancer Immunology Research] An epigenetic CRISPR-Cas9 screen of 1,218 chromatin regulators identified TRIM28 as a suppressor of PD-L1 expression.

[Cell Reports] To gain a deeper understanding of the molecular characteristics associated with CAR T cell differentiation, researchers performed longitudinal genome-wide DNA methylation profiling of CD8+ CD19-CAR T cells post-infusion in acute lymphoblastic leukemia patients.

[Molecular Therapy-Oncolytics] A novel DNA vaccine containing dual antigens of fibrinogen-like protein 1 and carbonic anhydrase IX was developed and intramuscularly delivered by PLGA/PEI nanoparticles for renal cancer therapy.