Dual-Targeting Vaccine of FGL1/CAIX Exhibits Potent Anti-Tumor Activity by Activating Dendritic Cells Mediated Multi-Functional CD8 T Cell Immunity

A novel DNA vaccine containing dual antigens of fibrinogen-like protein 1 and carbonic anhydrase IX was developed and intramuscularly delivered by PLGA/PEI nanoparticles for renal cancer therapy.