COPD

[BMJ Open] Researchers investigated the safety and potential therapeutic efficacy of allogeneic administration of umbilical cord-derived MSCs as a supplementary intervention in combination with standard COPD medication treatments in patients with moderate-to-severe COPD.

[CSA Medical, Inc. (Cision US, Inc.)] CSA Medical, Inc. announced that all subjects have been enrolled in the RejuvenAir® System study. The aim of this study is to determine the mechanism by which Metered CryoSpray reduces the density of goblet cells responsible for over-producing mucus and observe re-growth of healthy cilia in the airways.

[Scientific Reports] The authors showed thattransient receptor potential ankyrin 1 ( TRPA1) was likely an important link between cigarette smoke(CS) /cigarette smoke extract (CSE) exposure and airway hyperresponsiveness, and speculated that acute CS/CSE-induced Ca2+ influx could lead to exacerbated airway smooth muscle contraction and potentially initiate further chronic pathological effects of tobacco smoke.

[Scientific Reports] Researchers suggest that HHIP repressed aerobic glycolysis and airway smooth muscle cells hyperplasia, which might contribute to the increased airway remodeling in Hhip+/- mice.

[Thorax] Small airways from patients with COPD showed thickening of epithelial and subepithelial tissue, mucus plugging and reduced collagen density in the airway wall in severe COPD.

[Scientific Reports] Scientists investigated the modulation of T-helper 17 cell differentiation by the miR-21/Smad7/TGF-β pathway, and their roles in chronic obstructive pulmonary disease (COPD).