EMT

[Cell Death & Disease] The loss-of-function assays were used to investigate the effects of trafficking protein 3 on proliferation, apoptosis, cell cycle, and migration of lung squamous cell carcinoma cells.

[Biomedicine & Pharmacotherapy] Homemade ethanol-based garlic extract was administered to MCF7 and MCF10DCIS breast tumor cell lines grown under moderate hypoxia. Cell cycle, epithelial-to-mesenchymal transition and cancer stem cell markers were evaluated.

[Human & Experimental Toxicology] Lysine-specific demethylase 1 significantly impacted on the progression of TGF-β1-mediated epithelial-mesenchymal transition and ECM deposition in HK-2 cells, and it may represent novel target for the prevention strategies of renal fibrosis.

[Bioengineered] To identify how circular RNA circRNA_0082835 impacts melanoma cells and lymphatic metastasis to observe whether it exerts effects through its action mechanism of sponging microRNA miR-429.

[Cancer Cell International] Investigators summarize mechanisms of Wnt/β-catenin signaling for resistance development in TNBC, the complex interaction between Wnt/β-catenin signaling, and the transactivated receptor tyrosine kinase signaling pathways, lymphocytic infiltration, epithelial-mesenchymal transition, and induction of metastasis.

[Oncogenesis] The authors revealed that an elevated expression of transcription factor E2F1 and increased CpG hydroxymethylation of the E2F1 binding motif conjointly induced ESRP1 expression in breast carcinoma.