EMT

[Proteomics] The authors reported that doublecortin‐like kinase 1 (DCLK1) influences small extracellular vesicle biogenesis in a kinase‐dependent manner.

[Prostate] The authors showed that the loss of cell surface expression of Na/K‐ATPase α1 induced epithelial–mesenchymal transition and promoted metastatic potential and tumor growth of prostate cancer by decreasing the expression of E‐cadherin and increasing c‐Myc expression via the activation of Src/FAK pathways.

[Cell Death & Differentiation] Researchers showed that vimentin phosphorylated by PLK1, triggered TGF-β-signaling, which consequently led to metastasis and PD-L1 expression for immune suppression in lung adenocarcinoma.

[JCI Insight] Investigators performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy.

[Oncology Reports] Scientists demonstrated that the expression levels of MDM2 proto‑oncogene, E3 ubiquitin protein ligase were markedly increased in TGF‑β‑induced epithelial‑to‑mesenchymal transition using quantitative PCR and western blotting.

[Cell Death Discovery] Investigators explored thyroid hormone receptor interactor 12's role in the inhibition of epithelial-mesenchymal transition and implied a potential suppressive role in breast cancer metastasis.