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Pulmonary Cell NewsResearchers showed that vimentin phosphorylated by PLK1, triggered TGF-β-signaling, which consequently led to metastasis and PD-L1 expression for immune suppression in lung adenocarcinoma.
[Cell Death & Differentiation]
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Jang, H.-R., Shin, S.-B., Kim, C.-H., Won, J.-Y., Xu, R., Kim, D.-E., & Yim, H. (2021). PLK1/vimentin signaling facilitates immune escape by recruiting Smad2/3 to PD-L1 promoter in metastatic lung adenocarcinoma. Cell Death & Differentiation, 1–20. https://doi.org/10.1038/s41418-021-00781-4 Cite
