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Fos

RNA-Seq of Human T Cells after Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Regulator of T Cell Alloimmunity

[Science Translational Medicine] Linc00402 was increased in donor T cells from patients who underwent allogeneic cardiac transplantation and in murine T cells.

In Vivo CRISPR Inactivation of Fos Promotes Prostate Cancer Progression by Altering the Associated AP-1 Subunit Jun

[Oncogene] Whereas both JUN and FOS have been implicated in prostate cancer, the authors provided evidence that FOS acts as a tumor suppressor during prostate cancer progression and invasion.

FOS Licenses Early Events in Stem Cell Activation Driving Skeletal Muscle Regeneration

[Cell Reports] Investigators identified a prominent FBJ osteosarcoma oncogene mRNA and protein signature in recently activated satellite cells that was rapidly, heterogeneously, and transiently induced by muscle damage.

GDF15 Promotes Glioma Stem Cell-Like Phenotype via Regulation of ERK1/2–C-Fos–LIF Signaling

[Cell Death Discovery] The authors report that growth differentiation factor 15 (GDF15) promotes the glioma stem cell (GSC)-like phenotype in GSC-like cells through the activation of leukemia inhibitor factor (LIF)–STAT3 signaling.

Locally Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats

[Journal of Pain Research] Researchers developed an alginate scaffold with human umbilical cord mesenchymal stem cell exosomes to treat nerve injury-induced pain. In vitro studies of PC12 and HEK293 cells were used to evaluate the neuroprotective and neurotrophic effects of exosomes.

Recurrent FOS Rearrangement in Proliferative Fasciitis/Proliferative Myositis

[Modern Pathology] c-FOS immunohistochemistry was negative in 45 cases of selected mesenchymal tumor types with epithelioid components that may histologically mimic PF/PM, including pleomorphic sarcoma with epithelioid features and epithelioid sarcoma.

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