IL-6

[European Respiratory Journal] Scientists evaluated MUC5B variant rs35705950, telomere length, and serum levels of matrix metalloproteinase (MMP)-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, interleukin (IL)-6, surfactant protein (SP)-D, α-Klotho and resistin.

[Cell] Researchers demonstrated that TBK1 loss resulted in hypomorphic but sufficient IFN-I induction via RIG-I/MDA5, while the system retained near intact IL-6 induction through NF-κB.

[Scientific Reports] Scientists showed that interaction with tumor microenvironment elements, mainly activated monocytes through IL-6 secretion, and the extracellular matrix protein fibronectin, induced the Stat3 transcriptional pathway and upregulated ODZ1 which resulted in glioblastoma cell migration.

[Phytotherapy Research] Researchers reported a compound, trilobolide-6-O-isobutyrate, isolated from the flowers of Wedelia trilobata with a markedly cytotoxic effect on hepatocellular carcinoma cells.

[Nature Communications] Scientists showed a distinct mechanism by which SARS-CoV-2 N protein promoted NLRP3 inflammasome activation to induce hyperinflammation.

[Journal of Immunology] Investigators reported that TLR4 was expressed on granulo-monocytic progenitors, as well as mobilized human peripheral blood CD34+ cells. LPS, a component of Gram-negative bacteria that results in a systemic bacterial infection, induced the differentiation of peripheral blood CD34+ cells into myelocytes and monocytes in vitro via the TLR4 signaling pathway.