IL-6

[Cell Death & Disease] Scientists reported the role of Lon in the response to cisplatin-induced mtDNA damage and oxidative stress, which conferred cancer cells on cisplatin resistance via modulating calcium levels in mitochondria and cytosol.

[npj Parkinsons Disease] Using two chimeric mouse models, scientists demonstrated that the replacement of mutant LRRK2 with wild-type formed of the protein in T- and B-lymphocytes diminished LPS-mediated inflammation and rescued the substantia nigra pars compacta dopamine neuron loss in the mutant LRRK2 brain.

[Cell Death Discovery] Researchers investigated the role of histone deacetylase 11 (HDAC11) in vascular endothelial cell pyroptosis and its molecular mechanism.

[Clinical Rheumatology] Scientists investigated the structural and functional changes in the localized scleroderma (LSc) epidermis and further explored the underlying mechanisms, providing a new angle to treat LSc in the clinic.

[Fundamental & Clinical Pharmacology] The changes in gene expression profiles of multidrug resistant prostate cancer cells that were established in response to docetaxel were determined using microarray analysis.

[Journal of Agricultural and Food Chemistry] The miRNA profiles in ginger and ginger exosome-like nanoparticles were analyzed using high-throughput sequencing, and the results of the sequencing were validated by real-time quantitative polymerase chain reaction.