MAPK

[Cell Death & Disease] Researchers investigated whether cetuximab-mediated regulation of p38/Nrf2/HO-1 promoted RSL3-induced ferroptosis and played a pivotal role in overcoming drug resistance in KRAS mutant colorectal cancer.

[Laboratory Investigation] Based on the immunohistochemical analysis of breast cancer tissues from 497 patients, the authors demonstrated that matrix metalloproteinase 11 (MMP11) expression in mononuclear inflammatory cells was an independent negative prognostic factor in breast cancer, whereas MMP11 expression in tumor cells and fibroblasts was not associated with patient survival.

[Genome Medicine] Investigators identified 145 genes from IBD-associated genomic loci having endogenous expression within the intestinal epithelial cell compartment.

[Cell Death Discovery] The authors demonstrated that MMP1 derived from tumor-associated macrophages markedly facilitated colon cancer cell proliferation via accelerating cell cycle transition from G0/G1 to S and G2/M phase.

[PLoS One] Investigators established a model for interleukin 1β (IL-1β)-induced dermatitis and investigated mitogen-activated protein kinase signaling pathways in IL-1β-induced interleukin 8 (IL-8) expression.

[Cell Reports] The authors demonstrated that β-transducin repeat-containing protein (β-TrCP) targeted Tfcp2l1 for ubiquitination and degradation in a mitogen-activated protein kinase-activated protein kinase 2 (MK2)-dependent manner.