MAPK

[Developmental Cell] Scientists provided the proof-of-concept evidence for preventing pediatric low-grade gliomas before tumor-associated neurological damage entered an irreversible phase.

[Scientific Reports] Scientists evaluated the phenotype switching associated with drug resistance in breast cancer cell lines and cell lineage obtained from Brazilian patients and highlighted the role of the cancer stem cell marker CD24 in the dynamics of cell plasticity and the acquirement of drug resistance.

[Photodermatology Photoimmunology & Photomedicine] Scientists analyzed whether ultraviolet A aggravated the particulate matter-induced inflammatory cascade, which contributed to the aging of skin-derived cells.

[Stem Cell Reviews and Reports] Researchers found that the ex vivo expanded mesenchymal stem cells showed activated p38 mitogen-activated protein kinase p38 (MAPK) signaling and exhibited increased oxidative stress.

[Cancer Cell] Researchers compared the efficacies of sequential and/or combinatorial regimens in subcutaneous murine models of melanoma driven by BrafV600, Nras, or Nf1 mutations as well as colorectal and pancreatic carcinoma driven by KrasG12C.

[npj Precision Oncology] Using genetic as well as pharmacological tools, researchers showed that targeting the MEK5/ERK5 route was therapeutically effective in lung cancer.