MYC

[Cancer Cell International] Investigators characterized the function of eukaryotic translation initiation factors (eIFs) in epithelial-mesenchymal-transition (EMT) and metastasis in pancreatic cancer cells to investigate whether eIFs and downstream c-MYC affect EMT and metastasis by joint interference.

[Redox Biology] Researchers reported that β-glucan-trained macrophages from mice harboring a myeloid-specific deletion of the catalytic subunit of glutamate-cysteine ligase showed impaired GSH synthesis and decreased proinflammatory cytokine production in response to lipopolysaccharide challenge.

[Nature Communications] The authors demonstrated that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, established a pre-leukemic stage in which B cell precursors displayed self-renewal ability, initiating leukemia resembling PAX5 P80R or Ph-like human B-acute lymphoblastic leukemia.

[Biochemical Pharmacology] MICAL1 has been reported to be involved in the malignant processes of several types of cancer cells, however, the roles of MICAL1 in colorectal cancer (CRC) have not been well-characterized. Researchers investigated the cellular functions and molecular mechanisms of MICAL1 in CRCs.

[Journal of Surgical Oncology] The authors explored the expression level of miR-214-5p in prostate cancer and made a preliminary study of its molecular mechanism in the development of prostate cancer to provide effective new strategies for the treatment of prostate cancer.

[Molecular Pharmacology] Elevated expression of lysine demethylase 6A (KDM6A) and 6B (KDM6B) has been reported in prostate cancer (PCa). Scientists reported novel KDM6A/B downstream targets involved in controlling PCa cell proliferation.