NLRP3

[Stem Cell Research & Therapy] Bone-associated MSCs (BA-MSCs) were isolated from gene knockout mice, and the effect of Caspase-3/NLRP3 deficient BA-MSCs on hematopoiesis regulation was explored in vivo and ex vivo.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers reported that desmosterol, the most abundant cholesterol biosynthetic intermediate in human coronary artery lesions, played an essential role during atherogenesis, serving as a key molecule integrating cholesterol homeostasis and immune responses in macrophages.

[Oxidative Medicine and Cellular Longevity] Scientists showed that UVB provoked apoptosis-associated speck-like protein (ASC) speck formation in human primary keratinocytes prior to cell death, and that specks were, opposed to the perinuclear cytosolic localization in myeloid cells, formed in the nucleus.

[Bioengineered] Lipopolysaccharide was used to induce AUI in mice models and EPCs to mimic the realistic pathogenesis of intrauterine adhesion in vivo and in vitro.

[Food & Function] Researchers investigated the mechanisms through which the Tricholoma matsutake-derived peptide, WFNNAGP, exerted protective effects on the inflammatory response and oxidative stress in a dextran sodium sulfate (DSS)-induced IBD mouse model.

[Cell Death Discovery] Researchers evaluated the effects of Pgam5 on neurological deficits and neuroinflammation of controlled cortical impact-induced TBI mouse model in vivo and LPS+ ATP-induced microglia model in vitro.