Caspase-3/NLRP3 Signaling in the Mesenchymal Stromal Niche Regulates Myeloid-Biased Hematopoiesis

Bone-associated MSCs (BA-MSCs) were isolated from gene knockout mice, and the effect of Caspase-3/NLRP3 deficient BA-MSCs on hematopoiesis regulation was explored in vivo and ex vivo.