NSCLC

[Nature Communications] The authors developed a method that combines magnetic beads and flow cytometry cell sorting to isolate pericytes from tumors and normal adjacent tissues from patients with non-small cell lung cancer and hepatocellular carcinoma.

[npj Precision Oncology] A patient-derived cell line obtained at the time of disease progression was used to identify NRAS gene amplification as an additional driver of drug resistance to combination EGFR/MET therapies.

[Cell Death Discovery] The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.

[Cell Death & Differentiation] Based on an integrative analysis of The Cancer Genome Atlas database, investigators identified long non-coding RNA-RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) as one of the most highly upregulated lncRNAs that are associated with poor survival in non-small cell lung cancer.

[Cancer Cell] By functionally interrogating cancer-associated fibroblasts heterogeneity using the same therapeutics received by patients, the authors identified three functional subtypes: robustly protective of cancers and highly expressing HGF and FGF7; moderately protective of cancers and highly expressing FGF7; and those providing minimal protection.

[Scientific Reports] Researchers investigated the significance of sPD-L1 in cancer patients receiving immune checkpoint inhibitor therapy.