Nanog

[Toxicology and Applied Pharmacology] Investigators observed that proportion of CD133+Nanog+ subpopulation in MCF-7 cells was significantly increased after 3,3′-diindolylmethane administration with up-regulated AKT activity by using CyTOF assay.

[Cancer Letters] Scientists designed a meta-analysis to assess gene expression profiles in different breast cancer cell lines focusing on the secretory factors responsible for conversion.

[Development] Investigators reported that the conjunct activity of two orphan nuclear receptors, Esrrb and Nr5a2, paralleled the importance of that of Oct4 and Sox2 in naïve ESCs.

[Journal of Cellular and Molecular Medicine] Researchers compared the therapeutic potential of induced pluripotent stem cells differentiation into MSCs generated from urinary epithelial cells with the available umbilical cord MSCs.

[Cell Death & Disease] To identify drivers of sarcoma cancer stem-like cells, the authors compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids compared with the parent populations.

[iScience] The authors investigated whether ESCs retained memory of their previous states or transition in a memoryless (Markovian) process, and showed that some highly dynamic lineages of ESCs did not exhibit the Markovian property: their previous states and kin relations influenced future choices.