PBMCs

[Diabetologia] The authors investigated whether fenofibrate increased circulating hematopoietic stem/progenitor cells (HSPCs). When compared with placebo, fenofibrate significantly increased levels of HSPCs expressing CD34 and/or CD133.

[Cell Discovery] By performing scRNA/V(D)J-seq on peripheral blood mononuclear cells from four COVID-19 vaccine trial participants longitudinally during immunization, investigators revealed enhanced cellular immunity with concerted and cell type-specific IFN responses as well as boosted humoral immunity with SARS-CoV-2-specific antibodies.

[Cell Discovery] The authors used single-cell RNA sequencing to assess bone marrow mononuclear cells from COVID-19 patients with peripheral blood mononuclear cells as control, and showed that the HSCs in these patients were mainly in the G1 phase and prone to apoptosis, with immune activation and anti-viral responses.

[Signal Transduction and Targeted Therapy] Investigators inspected sex differences in SARS-CoV-2 infection, hospitalization, admission to the intensive care unit (ICU), sera inflammatory biomarker profiling, and single-cell RNA-sequencing profiles across nasal, bronchoalveolar lavage fluid, and peripheral blood mononuclear cells from COVID-19 patients with varying degrees of disease severities.

[Scientific Reports] Using a novel SARS-Cov-2-specific artificial antigen presenting cell, coupled with a rapid expansion protocol as practiced in tumor infiltrating lymphocytes therapy, researchers generated an immune catalytic quantity of VIL.

[Scientific Reports] The authors used recently described RNA ligands for toll-like receptor (TLR)7 and TLR8 together with Vγ9Vδ2 T-cell specific pyrophosphate antigens to analyze the rapid cytokine induction in Vδ2 T cells as well as the accessory cell requirements.