PD-1

[Frontiers in Immunology] Using various clinically and physiologically relevant systems, researchers showed that a prominent feature of PD-1-expressing exhausted T cells was the development of cellular senescence features both in vivo and ex vivo.

[Cancer Cell] Using multiple preclinical models of neoantigen-expressing pancreatic adenocarcinoma (PDAC), scientists demonstrated that intratumoral neoantigen-specific CD8+ T cells adopted multiple states of dysfunction, resembling those in tumor-infiltrating lymphocytes of PDAC patients.

[Mucosal Immunology] The authors interrogated the signatures of group 2 innate lymphoid cells from five tissues at the transcriptome and epigenetic level.

[Journal of Medicinal Chemistry] Researchers showed the efficacy of their most potent inhibitors in activating the antitumor response using primary human immune cells from healthy donors.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that Treg-expressed CTLA-4 facilitated Treg-antigen-presenting cells conjugation and immune synapse formation.

[Journal of Clinical Investigation] Starting with the observation that T cells moved more quickly through mouse tumors as residence time increased and they progressed towards exhaustion, the authors elaborated a non-stimulatory live-biopsy method for real-time study of T cell behaviors within individual patient tumors.