PI3K

[Cell Reports] Monocytes from stressed mice and humans exhibit a characteristic inflammatory transcriptomic signature and are hyperresponsive upon stimulation with Toll-like receptor ligands.

[Molecular Brain] The authors generated a human brain organoid model of increased PTEN dosage. They showed that mild PTEN overexpression led to reduced neural precursor proliferation, premature neuronal differentiation, and the formation of significantly smaller brain organoids.

[Archives of Toxicology] In vitro studies, such as DMPO immune-spin trapping assay, and dihydroethidium fluorescence assay on A549 and BEAS-2B cells demonstrated increased oxidative stress due to cobalt exposure.

[Cancer Letters] Scientists designed a meta-analysis to assess gene expression profiles in different breast cancer cell lines focusing on the secretory factors responsible for conversion.

[Respiratory Research] Researchers explored the role of tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) in the regulation of airway smooth muscle cells, which are one of the main effector cells in the development of asthma.

[International Journal of Stem Cells] Researchers investigated the potential role of irisin in the angiogenesis of bone-marrow mesenchymal stem cells (BMSCs). In vivo, irisin-treated BMSCs were transplanted into an myocardial infarction mouse model.