PTEN

[Cancer Research] Scientists reported that specific homozygous deletion of KDM6A in the adult mouse prostate epithelium strongly inhibited tumor progression initiated by the homozygous loss of PTEN. Mechanistically, KDM6A promoted prostate tumorigenesis and lipid metabolism by binding to the SREBP1c promoter which resulted in increased SREBP1c transcription.

[Movement Disorders] Investigators evaluated the difference between controls' and phosphatase and tensin homolog-induced putative kinase 1 (PINK1) patients' derived neurons in their transition from neuroepithelial stem cells to neurons, allowing them to identify potential pathways to target with repurposed compounds.

[Pigment Cell & Melanoma Research] Scientists investigated a case of melanoma that displayed a dual phenotype: a DPN-like/plexiform portion in conjunction with a conventional epithelioid morphology.

[Oral Diseases] Genetic variant was identified with exome sequencing. The human dental pulp cells isolated from a patient with Cowden syndrome were investigated for their proliferation, osteogenesis, adipogenesis, and gene expression compared with controls.

[iScience] The authors reported that myofibroblasts expressed and secreted PKM2. Extracellular PKM2 upregulated arginase-1 expression in myofibroblasts, therefore facilitating proline biosynthesis and subsequent collagen production.

[Cell Cycle] Researchers conducted quantitative reverse transcription PCR to find that circ_0004018 was down-regulated in hepatocellular carcinoma cells. Western blot analysis was performed to detect the protein levels of phosphatase and tensin homologue and related factors of PI3K/AKT signaling pathway.