Callender, L. A., Schroth, J., Carroll, E. C., Garrod-Ketchley, C., Romano, L. E. L., Hendy, E., Kelly, A., Lavender, P., Akbar, A. N., Chapple, J. P., & Henson, S. M. (2021). GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage. Nature Communications, 12(1), 3379. https://doi.org/10.1038/s41467-021-23715-7Cite
The authors discuss the association between PPARG genetic variants and drug efficacy, as well as the role of alternative splicing and post-translational modifications as contributors to the complexity of PPARγ signaling and to the effects of synthetic PPARγ ligands.
Using ChIP-Seq against NACA in parallel with RNA-sequencing, investigators report the identification of Ubiquitin Specific Peptidase 53 (Usp53) as a target gene of parathyroid hormone-activated nascent polypeptide associated complex and coregulator alpha in osteoblasts.
Angueira, A. R., Sakers, A. P., Holman, C. D., Cheng, L., Arbocco, M. N., Shamsi, F., Lynes, M. D., Shrestha, R., Okada, C., Batmanov, K., Susztak, K., Tseng, Y.-H., Liaw, L., & Seale, P. (2021). Defining the lineage of thermogenic perivascular adipose tissue. Nature Metabolism, 1–16. https://doi.org/10.1038/s42255-021-00380-0Cite