GATA3 Induces Mitochondrial Biogenesis in Primary Human CD4+ T Cells during DNA Damage

Investigators showed a mechanism utilised by CD4+ T cells to increase mitochondrial mass in response to DNA damage through the actions of GATA3 and AMPK.
[Nature Communications]
Callender, L. A., Schroth, J., Carroll, E. C., Garrod-Ketchley, C., Romano, L. E. L., Hendy, E., Kelly, A., Lavender, P., Akbar, A. N., Chapple, J. P., & Henson, S. M. (2021). GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage. Nature Communications, 12(1), 3379. https://doi.org/10.1038/s41467-021-23715-7 Cite
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PPARγ and Diabetes: Beyond the Genome and Towards Personalized Medicine

The authors discuss the association between PPARG genetic variants and drug efficacy, as well as the role of alternative splicing and post-translational modifications as contributors to the complexity of PPARγ signaling and to the effects of synthetic PPARγ ligands.
[Current Diabetes Reports]
Cataldi, S., Costa, V., Ciccodicola, A., & Aprile, M. (2021). PPARγ and Diabetes: Beyond the Genome and Towards Personalized Medicine. Current Diabetes Reports, 21(6), 18. https://doi.org/10.1007/s11892-021-01385-5 Cite
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Ubiquitin Specific Peptidase Usp53 Regulates Osteoblast versus Adipocyte Lineage Commitment

Using ChIP-Seq against NACA in parallel with RNA-sequencing, investigators report the identification of Ubiquitin Specific Peptidase 53 (Usp53) as a target gene of parathyroid hormone-activated nascent polypeptide associated complex and coregulator alpha in osteoblasts.
[Scientific Reports]
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Defining the Lineage of Thermogenic Perivascular Adipose Tissue

The cellular origins of perivascular adipose tissue are poorly understood. Investigators determined the identity of perivascular adipocyte progenitors in mice and humans
[Nature Metabolism]
Angueira, A. R., Sakers, A. P., Holman, C. D., Cheng, L., Arbocco, M. N., Shamsi, F., Lynes, M. D., Shrestha, R., Okada, C., Batmanov, K., Susztak, K., Tseng, Y.-H., Liaw, L., & Seale, P. (2021). Defining the lineage of thermogenic perivascular adipose tissue. Nature Metabolism, 1–16. https://doi.org/10.1038/s42255-021-00380-0 Cite
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PPAR-Gamma Induced AKT3 Expression Increases Levels of Mitochondrial Biogenesis Driving Prostate Cancer

A functional effect of Peroxisome Proliferator-Activated Receptor (PPAR)-Gamma on AKT serine/threonine kinase 3 (AKT3), which ultimately results in a more aggressive disease phenotype was identified.
[Oncogene]
PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer | Oncogene. (n.d.). Retrieved March 4, 2021, from https://www.nature.com/articles/s41388-021-01707-7 Cite
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Histone Deacetylase 3 Controls Lung Alveolar Macrophage Development and Homeostasis

Researchers showed that histone deacetylase 3 was a key epigenetic factor required for avelolar macrophage embryonic development, postnatal homeostasis, maturation, and regeneration from bone marrow.
[Nature Communications]
Yao, Y., Liu, Q., Adrianto, I., Wu, X., Glassbrook, J., Khalasawi, N., Yin, C., Yi, Q., Dong, Z., Geissmann, F., Zhou, L., & Mi, Q.-S. (2020). Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis. Nature Communications, 11(1), 3822. https://doi.org/10.1038/s41467-020-17630-6 Cite
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