Pparg

[Scientific Reports] Researchers found that miR-520a-5p bound the FZD9 3’UTR in lung cell lines and altered activity and expression of Frizzled 9 downstream targets.

[Cell Chemical Biology] Scientists revealed a functional duality of the Irs2 gene locus, where reciprocal changes of Irs2 and ASIrs2 in obesity caused insulin resistance and steatosis.

[Nature Communications] Investigators showed a mechanism utilised by CD4+ T cells to increase mitochondrial mass in response to DNA damage through the actions of GATA3 and AMPK.

[Current Diabetes Reports] The authors discuss the association between PPARG genetic variants and drug efficacy, as well as the role of alternative splicing and post-translational modifications as contributors to the complexity of PPARγ signaling and to the effects of synthetic PPARγ ligands.

[Scientific Reports] Using ChIP-Seq against NACA in parallel with RNA-sequencing, investigators report the identification of Ubiquitin Specific Peptidase 53 (Usp53) as a target gene of parathyroid hormone-activated nascent polypeptide associated complex and coregulator alpha in osteoblasts.

[Nature Metabolism] The cellular origins of perivascular adipose tissue are poorly understood. Investigators determined the identity of perivascular adipocyte progenitors in mice and humans