GATA3 Induces Mitochondrial Biogenesis in Primary Human CD4+ T Cells during DNA Damage

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Justin.choi
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Investigators showed a mechanism utilised by CD4+ T cells to increase mitochondrial mass in response to DNA damage through the actions of GATA3 and AMPK.
[Nature Communications]
Callender, L. A., Schroth, J., Carroll, E. C., Garrod-Ketchley, C., Romano, L. E. L., Hendy, E., Kelly, A., Lavender, P., Akbar, A. N., Chapple, J. P., & Henson, S. M. (2021). GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage. Nature Communications, 12(1), 3379. https://doi.org/10.1038/s41467-021-23715-7 Cite
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