RAS

[Cell Death & Disease] Ephexin1 was reported to be highly upregulated by oncogenic Ras, but the functional consequences of this remain poorly understood. The authors showed that Ephexin1 was highly expressed in colorectal cancer and lung cancer patient tissues.

[Oncogene] In human tissue samples and cell lines, xenografts, and genetic mouse models, NKX2-1 induced the ERK phosphatase DUSP6, which inactivates ERK.

[Scientific Reports] Researchers clarified how NKIRAS acted on cellular transformation, and generated transgenic mice in which NKIRAS2 was forcibly expressed using a cytokeratin 15 promoter, which was mainly activated in follicle bulge cells.

[Oncogene] Researchers investigated the biological effects of OLFM4-RET fusion and whether it could initiate tumorigenesis in small intestine.

[Biomedicine & Pharmacotherapy] Researchers characterized a novel 12-kDa protein that named musarin, which was purified from Trametes versicolor mushroom extract and showed significant growth inhibition on multiple human colorectal cancer cell lines in vitro.

[Science Advances] The authors examined the molecular mechanisms coordinating the naïve to primed transition by using inducible ESC to genetically eliminate all RAS proteins. They showed that differentiated RASKO ESCs remained trapped in an intermediate state of pluripotency with naïve-associated features.