ROS production

[Cell Death & Disease] Irisin effectively inhibited β-GP-induced calcium deposition in VSMCs in vitro and in mice aortic rings ex vivo. Overexpression of Nlrp3 attenuated the suppressive effect of Irisin on VSMC calcification.

[Biochimica Et Biophysica Acta-Molecular Cell Research] Researchers investigated the effects of GRK2 inhibitors on neutrophil functions induced by GPR84 and FPR2 agonists. GRK2 was shown to be expressed in human neutrophils and analysis of subcellular fractions revealed a cytosolic localization.

[Stem Cell Reports] Phospholamban (PLN) deletion in human induced pluripotent stem cell-cardiomyocytes had enhanced contractility at day 30, but proceeded to a cardiac failure phenotype at day 60, with decreased contractility, mitochondrial damage, increased reactive oxygen species production, cellular energy metabolism imbalance, and poor Ca2+ handling.

[Molecular Oncology] The glioblastoma tumoral mass was characterized by a small cellular subpopulation, glioblastoma stem cells that has been held responsible for glioblastoma initiation, cell invasion, proliferation, relapse and resistance to chemo and radiotherapy.

[PLoS Pathogens] Researchers showed that natural killer (NK) cells directly killed extracellular P. aeruginosa using NK effector molecules.

[Cell and Tissue Research] In vitro functionality testing showed that these expanded cells promoted angiogenesis and, in brain glial cells, promoted cell proliferation and reduced production of reactive oxygen species during oxidative stress.