GRK2 Selectively Attenuates the Neutrophil NADPH-Oxidase Response Triggered by β-Arrestin Recruiting GPR84 Agonists

Researchers investigated the effects of GRK2 inhibitors on neutrophil functions induced by GPR84 and FPR2 agonists. GRK2 was shown to be expressed in human neutrophils and analysis of subcellular fractions revealed a cytosolic localization.