SHH

[Science Translational Medicine] In mouse models of progressive osseous heteroplasia, a disease caused by null mutations in GNAS, researchers found that Gnas−/− mesenchymal cells secreted Sonic hedgehog (SHH), which induced osteoblast differentiation of the surrounding wild-type cells.

[Cell Death Discovery] Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.

[Scientific Reports] By analyzing retinal explants treated with selective ligands that target these receptors, we found that Sstr2-dependent somatostatin signaling induces a modest, dose-dependent inhibition of photoreceptor generation, while correspondingly increasing the relative fraction of primary progenitor cells.

[Journal of Biomedical Science] NKX6-1 enhanced in vitro tumor cell aggressiveness via upregulation of cell proliferation and anchorage-independent growth and promoted in vivo tumor growth.

[Stem Cell Reviews and Reports] Researchers evaluated single cell photonics as a discriminator of cell phenotype in vitro before the presence of vascular stem cells within vascular lesions.

[Nature Communications] Investigators report that bone-borne TGF-β induced the acetylation of transcription factor KLF5 in prostate cancer bone metastases, and acetylated KLF5 caused osteoclastogenesis and bone metastatic lesions by activating CXCR4, which led to IL-11 secretion, and stimulated SHH/IL-6 paracrine signaling.