STAT3

[FASEB Journal] Checkpoint kinase 1 (ChK1)-mediated Cancerous Inhibitor of PP2A (CIP2A) overexpression drove inhibition of PP2A and activated STAT3, then led to reactive astrogliosis and neurodegeneration in vitro.

[Science Advances] Investigators revealed that CCRL2 was up-regulated in primitive cells from patients with myelodysplastic syndrome and secondary AML.

[Frontiers in Immunology] Using a human in vitro tri-culture system of macrophages with activated autologous T cells and BRAFV600E mutant melanoma cells, scientists showed that activated T cells and the synthetic triterpenoid the methyl CDDO-Me attenuated immune suppression.

[Endocrine Journal] Human umbilical cord mesenchymal stem cells treatment significantly alleviated inflammation, reduced serum thyroid antibody levels, and decreased the ratios of IL-17α+/CD25+FOXP3+ cells and serum IFN-γ/IL-4 in experimental autoimmune thyroiditis rats.

[Respiratory Research] In vivo, intraperitoneal injection of Nifuroxazide relieved and reversed pulmonary fibrosis caused by bleomycin bronchial instillation.

[Science Advances] In this proof-of-concept study, the authors successfully established organoids from seven chordoma tumor samples obtained from five patients presenting with tumors in different sites and stages of disease.