Sox2

[Cell Death & Disease] ALKBH5 gain- or loss-of function could effectively reverse LKB1 regulated cell proliferation, colony formation, and migration of KRAS-mutated lung cancer cells.

[PLOS Genetics] The global transcriptome data of various tissues and cell lines and quantitative expression analysis of PSCs showed that ESRG expression was much higher than other human endogenous retrovirus type-Hs and tightly silenced after differentiation.

[Stem Cell Research & Therapy] Researchers generated iPSCs from 3 different GS-2 patients using lentiviral vectors. The iPSCs were characterized using flow cytometry and RT-PCR and tested for the expression of pluripotency markers. In vivo differentiation to cells from all three germlines was tested using a teratoma assay. In vitro differentiation of GS-2 iPSCs into hematopoietic stem and progenitor cells was done using Op9 feeder layers and specified media.

[Oncogene] Investigators present SFRP2 as a SOX2-antagonist with the capacity to induce a mesenchymal subtype transition in glioma cells located in vascular tumor areas, highlighting its role in glioblastoma tumor evolution and intratumoral heterogeneity.

[Cell and Bioscience] Scientists investigated the effect of direct contact of prostate cancer (PCa) cells with mesenchymal stem cells on the stemness of PCa and its mechanisms.

[Cell Death Discovery] Scientists performed a series of studies and determined that the expression of HIF1α, HIF2α and Sox2 was decreased after hyperbaric oxygen (HBO) and that HBO promoted glioblastoma cell proliferation through cell cycle progression, albeit with a decrease in stemness, thus contributing to chemosensitization via the inhibition of HIF1α/HIF2α-Sox2.