T cells

[Science] Researchers demonstrated mux-seq as a systematic approach to characterize cellular composition, identify transcriptional signatures, and annotate genetic variants associated with systemic lupus erythematosus.

[Science] Scientists developed an alternative strategy to isolate T cell receptor mutants that exhibited high activation signals coupled with low-affinity peptide-major histocompatibility complex binding through the acquisition of catch bonds.

[Open Biology] Scientists developed a CD8+ T cell and adult stem cell liver organoid system using a microfluidic chip to coculture 3D human liver organoids embedded in extracellular matrix with HLA-matched primary human T cells in suspension.

[Nature Biomedical Engineering] By analyzing a large number of T cells at the single-cell level on a microwell array, scientists showed that T cell activation could occur via cis interactions, and that such cis activation could be used to detect antigen-specific T cells and clone their T cell receptor within four days.

[Science Translational Medicine] The authors characterized blood samples collected from 51 preterm infants longitudinally at five time points, 20 healthy term infants at birth and age 3 to 16 weeks, and five healthy adults, and observed strong associations between type 2 immune polarization in circulating CD3+CD4+ T cells and cardiopulmonary illness, with odds ratios up to 24.

[Science Advances] To determine the potential for viral adaptation to T cell responses, scientists probed the full influenza virus genome by next-generation sequencing directly ex vivo from infected mice, in the context of an experimental T cell-based vaccine, an H5N1-based viral vectored vaccinia vaccine Wyeth/IL-15/5Flu, versus the current standard-of-care.