T cells

[Communications Biology] Using B16 mouse melanoma and CT26 colon carcinoma as models of stroma-poor tumors, researchers demonstrated that myeloid/dendritic cells were the main sources of TGFβ1 and TGFβ3.

[Scientific Reports] Scientists used mammary tumors with in situ immunomodulation consisting of intratumoral injections of Flt3L to mobilize conventional type-1 dendritic cells (cDC1s), local irradiation to induce immunogenic tumor cell death, and TLR3/CD40 stimulation to activate cDC1s.

[Angewandte Chemie-International Edition] By embedding the hepatitis C virus NS3 protease between the single-chain variable fragment and the hinge domain, investigators showed that the display of anti-CD19 single-chain variable fragment on CAR-T cells was positively correlated to the presence of a clinical hepatitis C virus NS3 protease inhibitor asunaprevir.

[Proceedings of the National Academy of Sciences of the United States of America] Zika virus infection of trophoblasts caused endoplasmic reticulum stress, which made them decidual NK targets by down-regulating HLA-C/G, natural killer inhibitory receptor ligands that helped maintain tolerance of the semiallogeneic fetus.

[eLife] Scientists constructed a recombinant protein named NMHC which consist of influenza viral conserved epitopes and a superantigen fragment.

[Science Advances] Using an immune “hot” mouse ovarian cancer model, scientists found that cancer-associated-MSCs drove CD8+ T cell tumor immune exclusion and reduced response to anti–PD-L1 immune checkpoint inhibitor via secretion of numerous chemokines.