T cells

[Science Translational Medicine] Investigators demonstrated that mRNA delivery by polymeric nanoparticles could effectively induce expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in Pten-mutated melanoma cells and Pten-null prostate cancer cells, which in turn induced autophagy and triggered cell death–associated immune activation via release of damage-associated molecular patterns.

[HUYABIO InternationalTM (PR Newswire, Inc.)] HUYABIO International™ announced the regulatory approval for HBI-8000 monotherapy of relapsed or refractory adult T-cell leukemia/lymphoma (ATL) by the Japanese Pharmaceuticals and Medical Devices Agency. The drug was approved based on data from a Phase IIb study that involved 23 patients with aggressive ATL in Japan.

[Journal of Clinical Oncology] Investigators conducted a pilot clinical trial of a humanized CD19 CAR T-cell product in children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia or B-lymphoblastic lymphoma, treated in two cohorts: with or without prior CAR exposure.

[Immunity] Researchers examined the effect of B cell stimuli on lymphoid stromal cells in follicular lymphoma (FL). FL B cells interacted primarily with CD49a+ fibroblastic reticular cells.

[Cell] Researchers showed that the skin microbiota promotes the discrete expression of defined endogenous retroviruses.

[Nature] Scientists discovered COVID-19 disease-associated microglia and astrocyte subpopulations that share features with pathological cell states reported in human neurodegenerative disease4–6.