T cells

[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated that citrulline administration was more efficient than arginine in increasing arginine plasma levels and restoring T cell mitochondrial function and proliferation while reducing sepsis-induced T regulatory cells and myeloid-derived suppressor cells expansion.

[Oncogene] Scientists demonstrate that activated T cells armed with anti-CD3 x anti-EGFR bispecific antibody increases tumor infiltrating lymphocytes and mediate anti-tumor cytotoxicity while decreasing tumor cell viability.

[Haematologica] Researchers designed a CD34/CD3 bispecific T-cell engager (BiTE) and characterized its anti-leukemia potential in vitro, ex vivo and in vivo.

[Proceedings of the National Academy of Sciences of the United States of America] In the absence of IFN-γ, lung innate lymphoid cells (ILC12) from mice challenged with the A/California/04/2009 H1N1 virus, containing nonfunctional viral PB1-F2, initiated a robust IL-5 response, which also led to improved tissue integrity and increased survival.

[Science Signaling] The authors investigated whether Themis plays a direct role in cytokine signaling in mature T cells.

[Biophysical Journal] Researchers found that in addition to increased cell motility, cancer cells exploited the elevated actomyosin force generation to remodel ECM and to deplete important co-stimulatory receptors on antigen presenting cells, facilitating tumor progression.