T cells

[NPJ Regenerative Medicine] Using a defined engineered thymic niche system, investigators undertook a multi-stage statistical learning-based optimization campaign and identified IL-3 and tumor necrosis factor α as a stage- and dose-specific enhancers of cell proliferation and T-lineage differentiation.

[Lyell Immunopharma, Inc. (Globenewswire, Inc.)] Lyell Immunopharma, Inc. announced that US FDA has cleared an Investigational New Drug (IND) application to initiate a Phase I clinical trial for LYL132, an investigational T-cell receptor therapy for patients with solid tumors expressing New York esophageal squamous cell carcinoma 1 that the company is developing in collaboration with GSK.

[Journal of Leukocyte Biology] Investigators used Oncomine and The Cancer Genome Atlas databases to analyze the transcription and survival effect of N-acetylgalactosaminyltransferase genes (GALNTs) in pan-cancer.

[Reproductive Sciences] Researchers assessed the correlation between immune infiltration status, chemotherapeutics sensitivity, immune checkpoint proteins, and the signature.

[Scandinavian Journal of Immunology] The authors analyzed the influence of its precursor 25-hydroxyvitamin D3 on the differentiation of human CD4+ T cells applying physiological concentrations in vitro.

[Nature Reviews Nephrology] The understanding of T cell memory responses changed drastically with the discovery that specialized T cell memory populations reside within peripheral tissues at key pathogen entry sites.