TLR4

[Cancer Research] Scientists showed follistatin-like 1 (FSTL1) expression to be closely correlated with activated fibroblasts and to be elevated in regenerative, fibrotic, and disease liver states in various mouse models. Consistently, FSTL1 lineage cells gave rise to myofibroblasts in a CCL4-induced hepatic fibrosis mouse model.

[Blood Cancer Journal] Investigators discuss the role and importance of inflammasomes and immune pathways in myeloid malignancies, particularly myelodysplastic syndromes/acute myeloid leukemia, to better understand the disease pathophysiology and decipher the scope of therapeutic interventions.

[Cell Communication and Signaling] Considerable attention has been focused on the regulation of TLR4 signaling in the context of colitis-associated tumorigenesis. MicroRNA-155 and TLR4 exhibited a similar dynamic expression change during colitis-associated cancer (CAC) development and shared similar CAC-promoting properties.

[Clinical and Experimental Pharmacology and Physiology] Investigators investigated the involvement of GRB2-associated binding protein 1 (GAB1) in septic lung injury. Lipopolysaccharide induced mouse model and A549 cell model were used to similar the septic lung injury.

[Cell Reports] The authors revealed that the immune-specific transmembrane adaptor SCIMP was a direct scaffold for Erk1/2 in TLR pathways, with high-resolution, live-cell imaging revealing that SCIMP guided the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling.

[Molecular Medicine Reports] The authors investigated whether serum exosomes played a pro‑inflammatory role in bronchial epithelial cells and explored the underlying molecular mechanisms.