SCIMP Is a Spatiotemporal Transmembrane Scaffold for Erk1/2 to Direct Pro-Inflammatory Signaling in TLR-Activated Macrophages

The authors revealed that the immune-specific transmembrane adaptor SCIMP was a direct scaffold for Erk1/2 in TLR pathways, with high-resolution, live-cell imaging revealing that SCIMP guided the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling.