caspase-3

[Acta Pharmacologica Sinica] In vitro, scientists found that DAPA inhibited the expression of cleaved caspase 3, Bax, C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the cardiomyoprotective protein Bcl-2 in angiotensin II (Ang II)-treated cardiomyocytes.

[Nanomedicine-Nanotechnology Biology and Medicine] Using in vitro oral squamous cell carcinoma CSCs and in vivo xenograft mice model, investigators systematically studied the apoptotic potentiality of Quinacrine-gold hybrid nanoparticle and its underlying mechanism after NIR irradiation.

[Photochemical & Photobiological Sciences] Investigators evaluated the potential of quercetin and its structurally related flavonoid taxifolin to reduce UVA-caused damage to human primary dermal fibroblasts and epidermal keratinocytes obtained from identical donors.

[Molecular Biology Reports] Scientists investigated the apoptotic effects of curcumin in the colon carcinoma cell line SW480. Cells were treated with 40–200 μM curcumin for 24, 48, and 72 hours, and the IC50 values were determined for each time interval.

[Stem Cell Research & Therapy] Bone-associated MSCs (BA-MSCs) were isolated from gene knockout mice, and the effect of Caspase-3/NLRP3 deficient BA-MSCs on hematopoiesis regulation was explored in vivo and ex vivo.

[Animal] To investigate the preservative effects of vascular endothelial growth factor sensitization on ceramide-mediated programmed cell death of cardiomyocytes, palmitate-induced injury in H9c2 cells was established as an in vitro model.